Effect of Hydrophilic Polymers on the Release Rate and Pharmacokinetics of Acyclovir Tablets Obtained by Wet Granulation: In Vitro and In Vivo Assays

Effect of Hydrophilic Polymers on the Release Rate and Pharmacokinetics of Acyclovir Tablets Obtained by Wet Granulation: In Vitro and In Vivo Assays

This study aims to evaluate the feasibility of producing acyclovir-containing modified release matrix tablets by a wet granulation method based on the type and concentration of two pharmaceutical-grade hydrophilic matrix polymers (i.e., hydroxypropyl methylcellulose (HPMC), carbomers, and their comb...

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Bibliographic Details
Main Authors: D. Nagasamy Venkatesh, Subramanianainar N. Meyyanathan, Andjelka Kovacevic, Aleksandra Zielińska, Joel Fonseca, Piotr Eder, Agnieszka Dobrowolska, Eliana B. Souto
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
acyclovir
hydrophilic polymers
sustained release profile
pharmacokinetics
in vitro and in vivo testing
Online Access:https://www.mdpi.com/1420-3049/27/19/6490

Internet

https://www.mdpi.com/1420-3049/27/19/6490

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