Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux

Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux

Abstract Background Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle function, a syndrome known as sarcopenia. R...

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Bibliographic Details
Main Authors: Josué Orozco-Aguilar, Franco Tacchi, Francisco Aguirre, Mayalen Valero-Breton, Mauricio Castro-Sepulveda, Felipe Simon, Claudio Cabello-Verrugio
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Biological Research
Subjects:
Sarcopenia
Ursodeoxycholic acid
Autophagic flux
Protein synthesis
Bile acids
Online Access:https://doi.org/10.1186/s40659-023-00431-8

Internet

https://doi.org/10.1186/s40659-023-00431-8

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