Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia

Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia

Abstract The antibody conjugate gemtuzumab ozogamicin (GO; Mylotarg®) provides targeted therapy of acute myeloid leukemia (AML), with recent approvals for patients with CD33-positive disease at diagnosis or relapse, as monotherapy or combined with chemotherapeutics. While its clinical efficacy is we...

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Bibliographic Details
Main Authors: Petra Hååg, Magnus Olsson, Jeremy Forsberg, Marita Lagergren Lindberg, Bo Stenerlöw, Dali Zong, Lena Kanter, Rolf Lewensohn, Kristina Viktorsson, Boris Zhivotovsky, Leif Stenke
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01071-9

Internet

https://doi.org/10.1038/s41420-022-01071-9

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