The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma

The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma

Immunotherapy resistance is common among melanoma patients. Here, the authors identify three resistance mechanism subtypes across tumor-derived cell lines and matched samples and highlight antigen presentation disruption as a key mediator of resistance.

Bibliographic Details
Main Authors: Su Yin Lim, Elena Shklovskaya, Jenny H. Lee, Bernadette Pedersen, Ashleigh Stewart, Zizhen Ming, Mal Irvine, Brindha Shivalingam, Robyn P. M. Saw, Alexander M. Menzies, Matteo S. Carlino, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36979-y

Internet

https://doi.org/10.1038/s41467-023-36979-y

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