Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission

Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission

Mitochondrial metabolism and dynamics (fission and fusion) critically regulate cell survival and proliferation, and abnormalities in these pathways are implicated in both neurodegenerative disorders and cancer. Mitochondrial fission is necessary for the growth of mutant Ras-dependent tumors. Here, w...

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Bibliographic Details
Main Authors: Dantong Zhu, Fengtong Han, Liuke Sun, Sandeep K. Agnihotri, Ying Hu, Hansruedi Büeler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
PTEN-induced kinase-1 (PINK1)
mitochondrial metabolism
mitochondrial dynamics
Ras protein
Ras-induced tumors
dynamin-related protein 1 (DRP1)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.893396/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.893396/full

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