Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I

Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I

There is a critical need for therapeutic approaches that combine renewable sources of replacement beta cells with localized immunomodulation to counter recurrence of autoimmunity in type 1 diabetes (T1D). However, there are few examples of animal models to study such approaches that incorporate spon...

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Bibliographic Details
Main Authors: Jorge Santini-González, Roberto Castro-Gutierrez, Matthew W. Becker, Chad Rancourt, Holger A. Russ, Edward A. Phelps
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
PD-L1
HLA Class I
type 1 diabetes
stem cell-derived beta cell
tolerance
beta cell replacement
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.989815/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.989815/full

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