Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis

Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis

Hypoxia impairs blood–brain barrier (BBB) structure and function, causing pathophysiological changes in the context of stroke and high-altitude brain edema. Brain microvascular endothelial cells (BMECs) are major structural and functional elements of the BBB, and their exact role in hypoxia remains...

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Bibliographic Details
Main Authors: Qixin Shi, Shaohua Li, Qiang Lyu, Shuai Zhang, Yungang Bai, Jin Ma
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
blood–brain barrier
miR-212-3p
MCM2
cell cycle
proliferation
Online Access:https://www.mdpi.com/1422-0067/24/3/2788

Internet

https://www.mdpi.com/1422-0067/24/3/2788

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