Multi-Omics Analysis in β-Thalassemia Using an <i>HBB</i> Gene-Knockout Human Erythroid Progenitor Cell Model

Multi-Omics Analysis in β-Thalassemia Using an <i>HBB</i> Gene-Knockout Human Erythroid Progenitor Cell Model

β-thalassemia is a hematologic disease that may be associated with significant morbidity and mortality. Increased expression of <i>HBG1/2</i> can ameliorate the severity of β-thalassemia. Compared to the unaffected population, some β-thalassemia patients display elevated <i>HBG1/2&...

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Bibliographic Details
Main Authors: Guoqiang Zhou, Haokun Zhang, Anning Lin, Zhen Wu, Ting Li, Xumin Zhang, Hongyan Chen, Daru Lu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
omics study
<i>HBB</i>
<i>HBG1/2</i>
HIF1 pathway
stress erythropoiesis
Online Access:https://www.mdpi.com/1422-0067/23/5/2807

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https://www.mdpi.com/1422-0067/23/5/2807

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