Effect of Siponimod on Brain and Spinal Cord Imaging Markers of Neurodegeneration in the Theiler’s Murine Encephalomyelitis Virus Model of Demyelination

Effect of Siponimod on Brain and Spinal Cord Imaging Markers of Neurodegeneration in the Theiler’s Murine Encephalomyelitis Virus Model of Demyelination

Siponimod (Sp) is a Sphingosine 1-phosphate (S1P) receptor modulator, and it suppresses S1P- mediated autoimmune lymphocyte transport and inflammation. Theiler’s murine encephalomyelitis virus (TMEV) infection mouse model of multiple sclerosis (MS) exhibits inflammation-driven acute and chronic phas...

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Bibliographic Details
Main Authors: Suyog Pol, Ravendra Dhanraj, Anissa Taher, Mateo Crever, Taylor Charbonneau, Ferdinand Schweser, Michael Dwyer, Robert Zivadinov
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
TMEV
MRI
brain atrophy
spinal cord
siponimod
Online Access:https://www.mdpi.com/1422-0067/24/16/12990

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https://www.mdpi.com/1422-0067/24/16/12990

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