AUP1 Regulates the Endoplasmic Reticulum-Associated Degradation and Polyubiquitination of NKCC2

AUP1 Regulates the Endoplasmic Reticulum-Associated Degradation and Polyubiquitination of NKCC2

Inactivating mutations of kidney Na-K-2Cl cotransporter NKCC2 lead to antenatal Bartter syndrome (BS) type 1, a life-threatening salt-losing tubulopathy. We previously reported that this serious inherited renal disease is linked to the endoplasmic reticulum-associated degradation (ERAD) pathway. The...

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Bibliographic Details
Main Authors: Nadia Frachon, Sylvie Demaretz, Elie Seaayfan, Lydia Chelbi, Dalal Bakhos-Douaihy, Kamel Laghmani
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
kidney
ion transport
ER quality control
ERAD
AUP1
Bartter syndrome
Online Access:https://www.mdpi.com/2073-4409/13/5/389

Internet

https://www.mdpi.com/2073-4409/13/5/389

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