Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trialResearch in context

Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trialResearch in context

Summary: Background: Mucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic administration because lower doses are required for protection. Clinical development of mucosal mAbs is a highly active field yet clinical proof-of-conce...

Full description

Bibliographic Details
Main Authors: Natalie I. Mazur, Yvette N. Löwensteyn, Jonne Terstappen, Jeanette Leusen, Fred Schobben, Daniela Cianci, Peter M. van de Ven, Stefan Nierkens, Louis J. Bont, Elisabeth E. Nibbelke, Brigitte Buiteman, Neele Rave, Marlies Vermaas-van Putten, Elly A. Smit-Kleinlugtenbeld, Jacqueline P. de Lege-Korstanje, Marieke G. Peetsold, Anthon Hulsmann, Sandy van Gool, Yvonne Snepvangers, Max Colombijn, Negassi Menelik, Stephanie de Crom, Ben Semmekrot, Wouter J. de Waal, Eline Okhuijsen, Gavin W. ten Tusscher, Ronald A. de Moor, Mijke A. Breukels, Claire Lutterman, Gerdien A. Tramper-Stranders, Johanna H. Oudshoorn, Astrid Ritman, Jeannette S. von Lindern, Gerdina H. Dubbink-Verheij, Maartje M. van den Berg, Marlon E.F. Wilsterman, Edwin Rietveld, Willemijn van Heel, Anne M. de Grauw, Femke Croes, Rienus A. Doedens, Lonneke van Onzenoort-Bokken, Clemens B. Meijssen, Machteld van Scherpenzeel-de Vries, Petra Hoekstra, Linda G.M. van Rooij, Willem-Pieter de Boode, Maaike C. van Rossem, Petra Sipkema, Monique A.M. Jacobs, Marianne A. van Houten, Indrani Kok-Wijesinha, Arine M. Vlieger, Walter Balemans, Frans B. Plötz, Naomi Reijmerink, Stefan M. van Dorth, Willem Heikens, Anke G. Kuijpers, Christel Geesing, Bas J.P. Delsing, Mieke Aldenhoven, Karoly Illy, Eric Hack, Floris Groenendaal, Nicole Derksen, Katrien Oude Rengerink, Jan Meeldijk, Lysette Ebskamp-van Raaij, Jolanda D.F. de Groot-Mijnes, Rob Schuurman
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:EClinicalMedicine
Subjects:
Intranasal administration
Respiratory syncytial virus infections
Monoclonal antibody
Infant
Preventive medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023005011

Internet

http://www.sciencedirect.com/science/article/pii/S2589537023005011

Similar Items