Fine-Tuning of mTORC1-ULK1-PP2A Regulatory Triangle Is Crucial for Robust Autophagic Response upon Cellular Stress

Fine-Tuning of mTORC1-ULK1-PP2A Regulatory Triangle Is Crucial for Robust Autophagic Response upon Cellular Stress

Autophagy-dependent cellular survival is tightly regulated by both kinases and phosphatases. While mTORC1 inhibits autophagy by phosphorylating ULK1, PP2A is able to remove this phosphate group from ULK1 and promotes the key inducer of autophagosome formation. However, ULK1 inhibits mTORC1, mTORC1 i...

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Bibliographic Details
Main Authors: Bence Hajdú, Marianna Holczer, Gergely Horváth, Gábor Szederkényi, Orsolya Kapuy
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
mTORC1
PP2A
ULK1
autophagy
systems biology
feedback loop
Online Access:https://www.mdpi.com/2218-273X/12/11/1587

Internet

https://www.mdpi.com/2218-273X/12/11/1587

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