Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway

Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway

Abstract Background Hypertrophic scar (HS), a fibroproliferative disorder caused by aberrant wound healing following skin injuries such as burns, lacerations and surgery, is characterized by invasive proliferation of fibroblasts and excessive extracellular matrix (ECM) accumulation. The dysregulati...

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Bibliographic Details
Main Authors: Hongxin Chen, Kai Xu, Chao Sun, Si Gui, Juanjuan Wu, Song Wang
Format: Article
Language:English
Published: Sociedade Brasileira de Dermatologia 2023-04-01
Series:Anais Brasileiros de Dermatologia
Subjects:
Autophagy
Angiopoietin-2
Cell proliferation
Cicatrix, hypertrophic
Class II phosphatidylinositol 3-kinases
Extracellular matrix
Fibroblast
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000100026&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000100026&lng=en&tlng=en

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