Mechanism of Action of Oral <i>Salmonella</i>-Based Vaccine to Prevent and Reverse Type 1 Diabetes in NOD Mice

Mechanism of Action of Oral <i>Salmonella</i>-Based Vaccine to Prevent and Reverse Type 1 Diabetes in NOD Mice

A combination therapy of preproinsulin (PPI) and immunomodulators (TGFβ+IL10) orally delivered via genetically modified <i>Salmonella</i> and anti-CD3 promoted glucose balance in in NOD mice with recent onset diabetes. The <i>Salmonella</i> bacteria were modified to express t...

Full description

Bibliographic Details
Main Authors: Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Mahmoud Singer, Fouad Kandeel, Mohamed I. Husseiny
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Vaccines
Subjects:
<i>Salmonella</i>-based vaccine
regulatory cells
tolerogenic dendritic cell (Tol-DC)
type 1 diabetes (T1D)
tolerance
oral vaccination
Online Access:https://www.mdpi.com/2076-393X/12/3/276

Internet

https://www.mdpi.com/2076-393X/12/3/276

Similar Items