Mechanism of Action of Oral <i>Salmonella</i>-Based Vaccine to Prevent and Reverse Type 1 Diabetes in NOD Mice

Mechanism of Action of Oral <i>Salmonella</i>-Based Vaccine to Prevent and Reverse Type 1 Diabetes in NOD Mice

A combination therapy of preproinsulin (PPI) and immunomodulators (TGFβ+IL10) orally delivered via genetically modified <i>Salmonella</i> and anti-CD3 promoted glucose balance in in NOD mice with recent onset diabetes. The <i>Salmonella</i> bacteria were modified to express t...

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Manylion Llyfryddiaeth
Prif Awduron: Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Mahmoud Singer, Fouad Kandeel, Mohamed I. Husseiny
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: MDPI AG 2024-03-01
Cyfres:Vaccines
Pynciau:
<i>Salmonella</i>-based vaccine
regulatory cells
tolerogenic dendritic cell (Tol-DC)
type 1 diabetes (T1D)
tolerance
oral vaccination
Mynediad Ar-lein:https://www.mdpi.com/2076-393X/12/3/276

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https://www.mdpi.com/2076-393X/12/3/276

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