The Catalytic Subunit of <i>Schizosaccharomyces pombe</i> CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)

The Catalytic Subunit of <i>Schizosaccharomyces pombe</i> CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)

Positive cofactor 4 (PC4) is a transcriptional coactivator that plays important roles in transcription and DNA replication. In mammals, PC4 is phosphorylated by CK2, and this event downregulates its RNA polymerase II (RNAPII) coactivator function. This work describes the effect of fission yeast PC4...

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Bibliographic Details
Main Authors: Diego A. Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
phosphorylation
CK2
transcription
general transcription factors (GTFs)
RNA polymerase II
<i>Schizosaccharomyces pombe</i>
Online Access:https://www.mdpi.com/1422-0067/23/16/9499

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https://www.mdpi.com/1422-0067/23/16/9499

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