The role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair

The role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair

Abstract Background During aging, perturbation of muscle progenitor cell (MPC) constituents leads to progressive loss of muscle mass and accumulation of adipose and fibrotic tissue. Mesenchymal stem cells (MSCs) give rise to adipocytes and fibroblasts that accumulate in injured and pathological skel...

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Bibliographic Details
Main Authors: Aiping Lu, Chieh Tseng, Ping Guo, Zhanguo Gao, Kaitlyn E. Whitney, Mikhail G. Kolonin, Johnny Huard
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
PDGFRβ lineage cells
Aging
Muscle progenitor cell
Skeletal muscle injury
Fibrosis and fatty infiltration
Online Access:https://doi.org/10.1186/s13287-022-03072-y

Internet

https://doi.org/10.1186/s13287-022-03072-y

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