Tin(II) and Tin(IV) Complexes Incorporating the Oxygen Tripodal Ligands [(<i>η</i><sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Co{P(OEt)<sub>2</sub>O}<sub>3</sub>]<sup>−</sup>, (R = H, Me; Et = -C<sub>2</sub>H<sub>5</sub>) as Potent Inflammatory Mediator Inhibitors: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Tin(II) and Tin(IV) Complexes Incorporating the Oxygen Tripodal Ligands [(<i>η</i><sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Co{P(OEt)<sub>2</sub>O}<sub>3</sub>]<sup>−</sup>, (R = H, Me; Et = -C<sub>2</sub>H<sub>5</sub>) as Potent Inflammatory Mediator Inhibitors: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Metal complexes displaying antiplatelet properties is a promising research area. In our methodology, Platelet-Activating Factor (PAF), the most potent lipid pro-inflammatory mediator, serves as a biological probe. The antiplatelet activity is exerted by the inhibition of the PAF-induced aggregation...

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Bibliographic Details
Main Authors: Alexandros Kalampalidis, Artemis Damati, Demetrios Matthopoulos, Alexandros B. Tsoupras, Constantinos A. Demopoulos, Gregor Schnakenburg, Athanassios I. Philippopoulos
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
oxygen tripodal ligand
Kläui ligands
Sn(II) and Sn(IV) compounds
antiplatelet drugs
cytotoxicity
platelet-activating factor (PAF)
Online Access:https://www.mdpi.com/1420-3049/28/4/1859

Internet

https://www.mdpi.com/1420-3049/28/4/1859

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