Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities of the Products

Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities of the Products

The reaction of diethyl phosphite with triethyl orthoformate and a primary amine followed by hydrolysis is presented, and the reaction was suitable for the preparation of (aminomethylene)bisphosphonates. 3-Amino-1,2,4-triazole was chosen as an interesting substrate for this reaction because it posse...

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Bibliographic Details
Main Authors: Patrycja Miszczyk, Dorota Wieczorek, Joanna Gałęzowska, Błażej Dziuk, Joanna Wietrzyk, Ewa Chmielewska
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
organophosphorus chemistry
bisphosphonic acids
aminomethylenebisphosponates
three-component reaction
triazole
P-containing drugs
anti-proliferative activity
osteoclasts
UV-Vis spectroscopy
pH-titration
potentiometry
crystallography
Online Access:http://www.mdpi.com/1420-3049/22/2/254

Internet

http://www.mdpi.com/1420-3049/22/2/254

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