Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma.

Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma.

BACKGROUND:The BRAF(V600E) mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator of MST1 tumor suppressor pathways, is inactivated by hypermethylation of its promoter region in...

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Bibliographic Details
Main Authors: Seong Jin Lee, Min Hee Lee, Dong Wook Kim, Seongeun Lee, Songmei Huang, Min Jeong Ryu, Yong Kyung Kim, Sung Jin Kim, Soung Jung Kim, Jung Hwan Hwang, Sangphil Oh, Heeyeong Cho, Jin Man Kim, Dae-Sik Lim, Young Suk Jo, Minho Shong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3020965?pdf=render

Internet

http://europepmc.org/articles/PMC3020965?pdf=render

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