Mitochondrial DNA methylation is a predictor of immunotherapy response and prognosis in breast cancer: scRNA-seq and bulk-seq data insights

Mitochondrial DNA methylation is a predictor of immunotherapy response and prognosis in breast cancer: scRNA-seq and bulk-seq data insights

BackgroundAlterations in Mitochondrial DNA methylation (MTDM) exist in many tumors, but their role in breast cancer (BC) development remains unclear.MethodsWe analyzed BC patient data by combining scRNA-seq and bulk sequencing. Weighted co-expression network analysis (WGCNA) of TCGA data identified...

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Bibliographic Details
Main Authors: Yixuan Ma, Juan Du, Meini Chen, Ning Gao, Sijia Wang, Zhikuan Mi, Xiaoli Wei, Jumei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
breast cancer
mitochondrial DNA methylation (MTDM)
NCAPD3
immunotherapy
prognostic model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219652/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219652/full

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