Intercellular Transfer of Oncogenic <i>KRAS</i> via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

Intercellular Transfer of Oncogenic <i>KRAS</i> via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

Mutated forms of the RAS oncogene drive 30% of all cancers, but they cannot be targeted therapeutically using currently available drugs. The molecular and cellular mechanisms that create a heterogenous tumor environment harboring both mutant and wild-type RAS have not been elucidated. In this study,...

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Bibliographic Details
Main Authors: Snider Desir, Phillip Wong, Thomas Turbyville, De Chen, Mihir Shetty, Christopher Clark, Edward Zhai, Yevgeniy Romin, Katia Manova-Todorova, Timothy K. Starr, Dwight V. Nissley, Clifford J. Steer, Subbaya Subramanian, Emil Lou
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
tunneling nanotubes
intercellular communication
<i>KRAS</i>
oncogene
cellular reprogramming
intercellular transfer
colon cancer
colorectal cancer
confocal microscopy
Online Access:https://www.mdpi.com/2072-6694/11/7/892

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https://www.mdpi.com/2072-6694/11/7/892

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