On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1

The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is controversial, however. In the present work, we u...

Full description

Bibliographic Details
Main Authors: Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
brain cholesterol homeostasis
liver X receptor activation
27-hydroxycholesterol
24S-hydroxycholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422072

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520422072

Similar Items