Skeletal Muscle Na+ Channel Disorders

Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4. The main symptoms of these disorders are myotonia or periodic paralysis caused by changes in skeletal muscle fiber excitability. Symptoms o...

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Bibliographic Details
Main Authors: Dina eSimkin, Saïd eBendahhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00063/full