Protection of Testis against Lipopolysaccharide-Induced Toxicity: Mildronate-Induced L-Carnitine Depletion as a Modulator of Gut Microbiome Composition and Gastrointestinal Inflammation

Protection of Testis against Lipopolysaccharide-Induced Toxicity: Mildronate-Induced L-Carnitine Depletion as a Modulator of Gut Microbiome Composition and Gastrointestinal Inflammation

L-carnitine plays a critical role in sperm functioning and maintaining male fertility. Mildronate is a widely used drug for treating cardiovascular diseases. Mildronate inhibits L-carnitine biosynthesis and transport into cells while increasing glucose supply. Therefore, it is speculated that mildro...

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Bibliographic Details
Main Authors: Artem P. Gureev, Polina I. Babenkova, Veronika V. Nesterova, Arina D. Tsvetkova, Mariya V. Gryaznova, Ekaterina A. Shaforostova
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Gastrointestinal Disorders
Subjects:
mildronate
L-carnitine
lipopolysaccharide
mitochondrial DNA
male fertility
gut microbiome
Online Access:https://www.mdpi.com/2624-5647/5/4/44

Internet

https://www.mdpi.com/2624-5647/5/4/44

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