Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines
The tobacco-specific <i>N</i>-nitrosamines 4-(<i>N</i>-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and <i>N</i>′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke. They have b...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5109 |
| _version_ | 1797504404742471680 |
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| author | Yupeng Li Stephen S. Hecht |
| author_facet | Yupeng Li Stephen S. Hecht |
| author_sort | Yupeng Li |
| collection | DOAJ |
| description | The tobacco-specific <i>N</i>-nitrosamines 4-(<i>N</i>-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and <i>N</i>′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke. They have been classified as “carcinogenic to humans” by the International Agency for Research on Cancer. In 1998, we published a review of the biochemistry, biology and carcinogenicity of tobacco-specific nitrosamines. Over the past 20 years, considerable progress has been made in our understanding of the mechanisms of metabolism and DNA adduct formation by these two important carcinogens, along with progress on their carcinogenicity and mutagenicity. In this review, we aim to provide an update on the carcinogenicity and mechanisms of the metabolism and DNA interactions of NNK and NNN. |
| first_indexed | 2024-03-10T04:04:08Z |
| format | Article |
| id | doaj.art-3b2bbb436922441b870617350421c63c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:04:08Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3b2bbb436922441b870617350421c63c2023-11-23T08:27:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239510910.3390/ijms23095109Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-NitrosaminesYupeng Li0Stephen S. Hecht1Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USAMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USAThe tobacco-specific <i>N</i>-nitrosamines 4-(<i>N</i>-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and <i>N</i>′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke. They have been classified as “carcinogenic to humans” by the International Agency for Research on Cancer. In 1998, we published a review of the biochemistry, biology and carcinogenicity of tobacco-specific nitrosamines. Over the past 20 years, considerable progress has been made in our understanding of the mechanisms of metabolism and DNA adduct formation by these two important carcinogens, along with progress on their carcinogenicity and mutagenicity. In this review, we aim to provide an update on the carcinogenicity and mechanisms of the metabolism and DNA interactions of NNK and NNN.https://www.mdpi.com/1422-0067/23/9/5109metabolismDNA adductstobacco-specific <i>N</i>-nitrosaminesNNKNNN |
| spellingShingle | Yupeng Li Stephen S. Hecht Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines International Journal of Molecular Sciences metabolism DNA adducts tobacco-specific <i>N</i>-nitrosamines NNK NNN |
| title | Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines |
| title_full | Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines |
| title_fullStr | Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines |
| title_full_unstemmed | Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines |
| title_short | Metabolism and DNA Adduct Formation of Tobacco-Specific <i>N</i>-Nitrosamines |
| title_sort | metabolism and dna adduct formation of tobacco specific i n i nitrosamines |
| topic | metabolism DNA adducts tobacco-specific <i>N</i>-nitrosamines NNK NNN |
| url | https://www.mdpi.com/1422-0067/23/9/5109 |
| work_keys_str_mv | AT yupengli metabolismanddnaadductformationoftobaccospecificininitrosamines AT stephenshecht metabolismanddnaadductformationoftobaccospecificininitrosamines |