Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease
Conclusions: We first demonstrated that irisin alleviated cognitive impairment by inhibiting AhR/NF-κB-NLRP3-mediated pyroptosis of hippocampal neurons in CKD. Overall, irisin may have the potential to serve as a critical antipyroptotic agent for improving CKD-induced cognitive impairment.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/2662362 |