Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood

Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood

Abstract Background Endometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and infertility. Immune dysfunction includes insufficient immune lesion clearance, a pro-inflammatory endometrial environment, and systemic inflamm...

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Bibliographic Details
Main Authors: Júlia Vallvé-Juanico, Ashley F. George, Sushmita Sen, Reuben Thomas, Min-Gyoung Shin, Divyashree Kushnoor, Joshua J. Vásquez, Kim Chi Vo, Juan C. Irwin, Nadia R. Roan, Alexis J. Combes, Linda C. Giudice
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Medicine
Subjects:
Endometriosis
Macrophages
Monocytes
Mononuclear phagocytes
SIRPα
Innate immune
Online Access:https://doi.org/10.1186/s12916-022-02359-4

Internet

https://doi.org/10.1186/s12916-022-02359-4

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