Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species (ROS) but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic metabolism, understanding how Mtb manages eROS levels is essential yet ne...

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Bibliographic Details
Main Authors: Somnath Shee, Reshma T Veetil, Karthikeyan Mohanraj, Mayashree Das, Nitish Malhotra, Devleena Bandopadhyay, Hussain Beig, Shalini Birua, Shreyas Niphadkar, Sathya Narayanan Nagarajan, Vikrant Kumar Sinha, Chandrani Thakur, Raju S Rajmani, Nagasuma Chandra, Sunil Laxman, Mahavir Singh, Areejit Samal, Aswin N Seshasayee, Amit Singh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
redoxosome
endogenous ROS
lipid metabolism
methylcitrate cycle
carbon source
Online Access:https://elifesciences.org/articles/80218

Internet

https://elifesciences.org/articles/80218

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