The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization

The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization

Farzadfard et al. present a comprehensive analysis of a range of C-terminal truncations of aSN, linking the importance of high C-terminus charge for decreased fibrillation rates. The ability to formation oligomers, to disrupt synthetic vesicles and cell toxicity was reduced with truncated aSN, aidin...

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Bibliographic Details
Main Authors: Azad Farzadfard, Jannik Nedergaard Pedersen, Georg Meisl, Arun Kumar Somavarapu, Parvez Alam, Louise Goksøyr, Morten Agertoug Nielsen, Adam Frederik Sander, Tuomas P. J. Knowles, Jan Skov Pedersen, Daniel Erik Otzen
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03059-8

Internet

https://doi.org/10.1038/s42003-022-03059-8

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