Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of <i>Trypanosoma brucei rhodesiense</i>

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of <i>Trypanosoma brucei rhodesiense</i>

Rhodesain is the main cysteine protease of <i>Trypanosoma brucei rhodesiense</i>, the parasite causing the acute lethal form of Human African Trypanosomiasis. Starting from the dipeptide nitrile <b>CD24</b>, the further introduction of a fluorine atom in the <i>meta<...

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Bibliographic Details
Main Authors: Carla Di Chio, Santo Previti, Noemi Totaro, Fabiola De Luca, Alessandro Allegra, Tanja Schirmeister, Maria Zappalà, Roberta Ettari
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
cysteine protease
rhodesain inhibitors
dipeptide nitrile
curcumin
combination studies
Online Access:https://www.mdpi.com/1422-0067/24/10/8477

Internet

https://www.mdpi.com/1422-0067/24/10/8477

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