Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice.

The neuroendocrine effects of leptin on metabolism hold promise to be translated into a complementary therapy to traditional insulin therapy for diabetes and obesity. However, injections of leptin can provoke inflammation. We tested the effects of leptin, produced in the physiological adipocyte loca...

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Bibliographic Details
Main Authors: David J DiSilvestro, Emiliano Melgar-Bermudez, Rumana Yasmeen, Paolo Fadda, L James Lee, Anuradha Kalyanasundaram, Chen L Gilor, Ouliana Ziouzenkova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4824514?pdf=render