Treprostinil Reconstitutes Mitochondrial Organisation and Structure in Idiopathic Pulmonary Fibrosis Cells

Treprostinil Reconstitutes Mitochondrial Organisation and Structure in Idiopathic Pulmonary Fibrosis Cells

Idiopathic pulmonary fibrosis (IPF) presents as an incurable change in the lung tissue and mitochondrial dysfunction of unknown origin. Treprostinil, a prostacyclin analogue, has been suggested for IPF therapy. This study assessed the effect of treprostinil on the cAMP signalling and mitochondrial a...

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Bibliographic Details
Main Authors: Lei Fang, Wei-Chih Chen, Peter Jaksch, Antonio Molino, Alessandro Saglia, Michael Roth, Christopher Lambers
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
idiopathic pulmonary fibrosis
mitochondrial dysfunction
treprostinil
cellular signalling
remodelling
Online Access:https://www.mdpi.com/1422-0067/24/15/12148

Internet

https://www.mdpi.com/1422-0067/24/15/12148

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