Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden

Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden

ABSTRACT There is a critical need for improved pharmacodynamic markers for use in human tuberculosis (TB) drug trials. Pharmacodynamic monitoring in TB has conventionally used culture or molecular methods to enumerate the burden of Mycobacterium tuberculosis organisms in sputum. A recently proposed...

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Bibliographic Details
Main Authors: Emmanuel Musisi, Christian Dide-Agossou, Reem Al Mubarak, Karen Rossmassler, Abdul Wahab Ssesolo, Sylvia Kaswabuli, Patrick Byanyima, Ingvar Sanyu, Josephine Zawedde, William Worodria, Martin I. Voskuil, Rada M. Savic, Payam Nahid, J. Lucian Davis, Laurence Huang, Camille M. Moore, Nicholas D. Walter
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Series:Microbiology Spectrum
Subjects:
human
Mycobacterium tuberculosis
sputum
assay development
pharmacodynamics
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00481-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00481-21

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