Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

Abstract Background The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and damage. Results Through transcriptome-wide...

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Bibliographic Details
Main Authors: Pascal Schlosser, Jingning Zhang, Hongbo Liu, Aditya L. Surapaneni, Eugene P. Rhee, Dan E. Arking, Bing Yu, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee, Katalin Susztak, Josef Coresh, Morgan E. Grams
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Genome Biology
Subjects:
Genetics
Nephrology
Chronic kidney disease
Transcriptomics
Proteomics
GWAS
Online Access:https://doi.org/10.1186/s13059-023-02993-y

Internet

https://doi.org/10.1186/s13059-023-02993-y

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