Identifying Key Somatic Copy Number Alterations Driving Dysregulation of Cancer Hallmarks in Lower-Grade Glioma

Identifying Key Somatic Copy Number Alterations Driving Dysregulation of Cancer Hallmarks in Lower-Grade Glioma

Somatic copy-number alterations (SCNAs) are major contributors to cancer development that are pervasive and highly heterogeneous in human cancers. However, the driver roles of SCNAs in cancer are insufficiently characterized. We combined network propagation and linear regression models to design an...

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Bibliographic Details
Main Authors: Yao Zhou, Shuai Wang, Haoteng Yan, Bo Pang, Xinxin Zhang, Lin Pang, Yihan Wang, Jinyuan Xu, Jing Hu, Yujia Lan, Yanyan Ping
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
somatic copy number alteration
driver genes
random walk with restart
cancer hallmark
LGG
regression analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.654736/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.654736/full

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