Biochemistry, molecular genetics, and clinical aspects of hereditary angioedema with and without C1 inhibitor deficiency

Biochemistry, molecular genetics, and clinical aspects of hereditary angioedema with and without C1 inhibitor deficiency

Hereditary angioedema (HAE) is a rare disorder characterized by cutaneous and submucosal swelling caused mostly by excessive local bradykinin production. Bradykinin is a vasoactive peptide generated by the limited proteolysis of high molecular weight kininogen (HMWK) by plasma kallikrein via the con...

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Bibliographic Details
Main Authors: Toshiyuki Miyata, Takahiko Horiuchi
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Allergology International
Subjects:
Bradykinin
Contact activation system
C1 inhibitor
Hereditary angioedema
Serpin
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893023000424

Internet

http://www.sciencedirect.com/science/article/pii/S1323893023000424

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