Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Alzheimer's disease (AD) is the most common neurodegenerative disorder, tightly related with microglia phenotypic polarization, which finally results in the stimulation of β-amyloid peptides (Aβ) and promotion of phagocytosis of neuronal synaptic structures. Thus, constructing drug system to re...

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Bibliographic Details
Main Authors: Ze Li, Zhenyan Song, Chunxiang He, Jialong Fan, Wenjing Yu, Miao Yang, Ping Li, Rongsiqing Luo, Jinyong Zhou, Sijie Xu, Bin Liu, Shaowu Cheng
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials Today Advances
Subjects:
Alzheimer's disease
Microglia
Neuroinflammation
Nanoparticle
APP/PS1
Online Access:http://www.sciencedirect.com/science/article/pii/S2590049822001175

Internet

http://www.sciencedirect.com/science/article/pii/S2590049822001175

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