Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis

Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis

Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4+Foxp3+ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to IL-2 to elaborate numerous suppressive mechanisms t...

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Bibliographic Details
Main Authors: Hirohito Abo, Kyle L. Flannigan, Duke Geem, Vu L. Ngo, Akihito Harusato, Timothy L. Denning
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
IL-2
IL-5
Treg
eosinophil
ILC2
IBD
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00459/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00459/full

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