<i>Aggregatibacter actinomycetemcomitans</i> LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes

<i>Aggregatibacter actinomycetemcomitans</i> LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes

Leukotoxin (LtxA), from oral pathogen <i>Aggregatibacter actinomycetemcomitans</i>, is a secreted membrane-damaging protein. LtxA is internalized by &#946;2 integrin LFA-1 (CD11a/CD18)-expressing leukocytes and ultimately causes cell death; however, toxin localization in the host cel...

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Bibliographic Details
Main Authors: Edward T Lally, Kathleen Boesze-Battaglia, Anuradha Dhingra, Nestor M Gomez, Jinery Lora, Claire H Mitchell, Alexander Giannakakis, Syed A Fahim, Roland Benz, Nataliya Balashova
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pathogens
Subjects:
<i>aggregatibacter actinomycetemcomitans</i>
rtx toxin
localized aggressive periodontitis
lfa-1
leukotoxin (ltxa)
endocytosis
Online Access:https://www.mdpi.com/2076-0817/9/2/74

Internet

https://www.mdpi.com/2076-0817/9/2/74

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