The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsisResearch in context

The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsisResearch in context

Summary: Background: Sepsis is associated with T-cell exhaustion, which significantly reduces patient outcomes. Therefore, targeting of immune checkpoints (ICs) is deemed necessary for effective sepsis management. Here, we evaluated the role of SIGLEC5 as an IC ligand and explored its potential as...

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Main Authors: Roberto Lozano-Rodríguez, José Avendaño-Ortíz, Karla Montalbán-Hernández, Juan Carlos Ruiz-Rodríguez, Ricardo Ferrer, Alejandro Martín-Quirós, Charbel Maroun-Eid, Juan José González-López, Anna Fàbrega, Verónica Terrón-Arcos, María Gutiérrez-Fernández, Elisa Alonso-López, Carolina Cubillos-Zapata, María Fernández-Velasco, Rebeca Pérez de Diego, Pablo Pelegrin, Carlos García-Palenciano, Francisco J. Cueto, Carlos del Fresno, Eduardo López-Collazo
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:EBioMedicine
Subjects:
Sepsis
Immune checkpoint
SIGLEC5
T-cell exhaustion
Biomarker
HIF1α
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423004073

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http://www.sciencedirect.com/science/article/pii/S2352396423004073

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