p53 Codon 72 Polymorphism and Risk of Cervical Cancer

Storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compa...

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Main Authors: JOSÉ M OJEDA, SANDRA AMPUERO, PATRICIO ROJAS, RODRIGO PRADO, JORGE E ALLENDE, SARA A BARTON, RANAJIT CHAKRABORTY, FRANCISCO ROTHHAMMER
Format: Article
Language:English
Published: BMC 2003-01-01
Series:Biological Research
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200017