Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L

Abstract Background About 10% of the mouse genome is composed of endogenous retroviruses (ERVs) that represent a molecular fossil record of past retroviral infections. One such retrovirus, murine ERV-L (MuERV-L) is an env-deficient ERV that has undergone episodic proliferation, with the most recent...

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Bibliographic Details
Main Authors: Daniel Blanco-Melo, Robert J. Gifford, Paul D. Bieniasz
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Retrovirology
Online Access:http://link.springer.com/article/10.1186/s12977-018-0416-3