NK cells propagate T cell immunity following in situ tumor vaccination

NK cells propagate T cell immunity following in situ tumor vaccination

Summary: We report an in situ vaccination, adaptable to nearly any type of cancer, that combines radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific antibody and interleukin-2 (IL-2; 3xTx). In a phase I clinical trial, administration of 3xTx (with an immunocy...

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Bibliographic Details
Main Authors: Won Jong Jin, Justin C. Jagodinsky, Jessica M. Vera, Paul A. Clark, Cindy L. Zuleger, Amy K. Erbe, Irene M. Ong, Trang Le, Kaitlin Tetreault, Tracy Berg, Alexander L. Rakhmilevich, KyungMann Kim, Michael A. Newton, Mark R. Albertini, Paul M. Sondel, Zachary S. Morris
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015681

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http://www.sciencedirect.com/science/article/pii/S2211124723015681

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