Recombinant BCG-LTAK63 Vaccine Candidate for Tuberculosis Induces an Inflammatory Profile in Human Macrophages

Recombinant BCG-LTAK63 Vaccine Candidate for Tuberculosis Induces an Inflammatory Profile in Human Macrophages

Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain expressing the genetically detoxified A subunit of the thermolabile toxin from <i>Escherichia coli</i> (LTAK63) adjuvant (rBCG-LTAK63) has previously been shown to confer superior protect...

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Bibliographic Details
Main Authors: Carina C. dos Santos, Kimberley V. Walburg, Suzanne van Veen, Louis G. Wilson, Carlos E. M. Trufen, Ivan P. Nascimento, Tom H. M. Ottenhoff, Luciana C. C. Leite, Mariëlle C. Haks
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Vaccines
Subjects:
tuberculosis
BCG vaccination
recombinant BCG
gene expression profiling
cytokine profiling
primary human macrophages
Online Access:https://www.mdpi.com/2076-393X/10/6/831

Internet

https://www.mdpi.com/2076-393X/10/6/831

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