The innate immune receptor Nlrp12 suppresses autoimmunity to the retina

Abstract Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined. The NLR, Nlrp12, has been reported to both inhibit and pro...

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Bibliographic Details
Main Authors: Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting, Holly L. Rosenzweig
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:https://doi.org/10.1186/s12974-022-02425-x