Regulation of the cardiomyocyte transcriptome <it>vs </it>translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin

<p>Abstract</p> <p>Background</p> <p>Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of p...

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Bibliographic Details
Main Authors: Sugden Peter H, Tham El L, Cullingford Timothy E, Marshall Andrew K, Markou Thomais, Clerk Angela
Format: Article
Language:English
Published: BMC 2010-05-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/11/343