Liver-Derived TGF-β Maintains the EomeshiTbetlo Phenotype of Liver Resident Natural Killer Cells

Liver-Derived TGF-β Maintains the EomeshiTbetlo Phenotype of Liver Resident Natural Killer Cells

The adult human liver hosts a complex repertoire of liver resident and transient natural killer (NK) cell populations with diverse phenotypes and functions. Liver resident NK cells are CD56bright NK cells defined by a unique expression profile of transcription factors and cell surface markers (Eomes...

Full description

Bibliographic Details
Main Authors:	Cathal Harmon, Gráinne Jameson, Dalal Almuaili, Diarmaid D. Houlihan, Emir Hoti, Justin Geoghegan, Mark W. Robinson, Cliona O'Farrelly
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Immunology
Subjects:	TGF-β1 liver-resident NK cell TBET microenviroment Eomes
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01502/full

Similar Items

Human Hepatic CD56bright NK Cells Display a Tissue-Resident Transcriptional Profile and Enhanced Ability to Kill Allogenic CD8+ T Cells
by: Gráinne Jameson, et al.
Published: (2022-07-01)

Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature
by: Jamie A. Sugrue, et al.
Published: (2021-11-01)

Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent
by: Paul Kelly, et al.
Published: (2019-02-01)

Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function
by: Julián Piñeiro Fernández, et al.
Published: (2019-08-01)

Uncovering Resistance to Hepatitis C Virus Infection: Scientific Contributions and Unanswered Questions in the Irish Anti-D Cohort
by: Jamie A. Sugrue, et al.
Published: (2022-02-01)

β-Defensins: Farming the Microbiome for Homeostasis and Health
by: Kieran G. Meade, et al.
Published: (2019-01-01)

Evolutionary selection identifies critical immune-relevant genes in lung cancer subtypes
by: Kimberly A. Luddy, et al.
Published: (2022-08-01)

Human PSC-Derived Hepatocytes Express Low Levels of Viral Pathogen Recognition Receptors, but Are Capable of Mounting an Effective Innate Immune Response
by: Lena Fischer, et al.
Published: (2020-05-01)

Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke.
by: Donal O'Shea, et al.
Published: (2010-01-01)

Evidence of the adaptive evolution of immune genes in chicken
by: Cormican Paul, et al.
Published: (2009-12-01)

Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle
by: Mounir Adnane, et al.
Published: (2018-09-01)

Identification of a Porcine Liver EomeshighT-betlow NK Cell Subset That Resembles Human Liver Resident NK Cells
by: Steffi De Pelsmaeker, et al.
Published: (2019-10-01)

An oxidative stress-related signature for predicting the prognosis of liver cancer
by: Luling Wang, et al.
Published: (2023-01-01)

Microfluidic Model to Evaluate Astrocyte Activation in Penumbral Region following Ischemic Stroke
by: Kathryn M. Denecke, et al.
Published: (2022-07-01)

miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling.
by: Aideen S Collins, et al.
Published: (2013-01-01)

The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation
by: Hee Yeun Won, et al.
Published: (2021-05-01)

Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF
by: Manju Sharma, et al.
Published: (2019-05-01)

Long-term in vivo vitamin D3 supplementation modulates bovine IL-1 and chemokine responses
by: Cian Reid, et al.
Published: (2023-07-01)

Next generation sequencing reveals the expression of a unique miRNA profile in response to a gram-positive bacterial infection.
by: Nathan Lawless, et al.
Published: (2013-01-01)

Early Subretinal Allograft Rejection is Characterized by Innate Immune Activity
by: Kevin P. Kennelly, et al.
Published: (2017-06-01)

TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment
by: Nouria Jantz-Naeem, et al.
Published: (2023-02-01)

Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
by: Gabriele Gaggero, et al.
Published: (2022-08-01)

Enhanced thrombin generation potential and endothelial dysfunction in chronic spontaneous urticaria
by: Katie Ridge, et al.
Published: (2023-07-01)

Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?
by: Irina Kareva, et al.
Published: (2021-08-01)

Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis
by: Martina Di Giovangiulio, et al.
Published: (2019-09-01)

Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8+ Cytotoxic T-Cells: Implications for anti-PD-1 Immunotherapy
by: Alison Taylor, et al.
Published: (2017-12-01)

Near-infrared TBET cassette with ultra large stokes shift and its application for SO2 imaging in cells
by: Gui Yun Duan, et al.
Published: (2021-11-01)

The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis
by: Robert J. Ju, et al.
Published: (2018-11-01)

A Simplified Laser System for Atom Interferometry Based on a Free-Space EOM
by: Bin Wu, et al.
Published: (2022-04-01)

Regulatory factor identification for nodal genes in zebrafish by causal inference
by: Cencan Xing, et al.
Published: (2022-10-01)

Modulation of T-bet and Eomes during Maturation of Peripheral Blood NK cells Does Not Depend on Licensing/Educating KIR
by: Amandine Pradier, et al.
Published: (2016-08-01)

The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity.
by: Jean O'Connell, et al.
Published: (2010-01-01)

Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV.
by: Nigel J Stevenson, et al.
Published: (2011-01-01)

The Genomics of Hairy Cell Leukaemia and Splenic Diffuse Red Pulp Lymphoma
by: David Oscier, et al.
Published: (2022-01-01)

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment
by: Aliyah M. Weinstein, et al.
Published: (2017-06-01)

Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops
by: Conor D. Talbot, et al.
Published: (2022-08-01)

Metabolic codependencies in the tumor microenvironment and gastric cancer: Difficulties and opportunities
by: Xihe Zhao, et al.
Published: (2023-06-01)

Identification of two molecular subtypes and a novel prognostic model of lung adenocarcinoma based on a cuproptosis-associated gene signature
by: Jinlin Zhou, et al.
Published: (2023-01-01)

The Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing
by: Li S, et al.
Published: (2022-02-01)

Editorial: The Bone Marrow Niche in Normal and Malignant Haematopoiesis
by: Michela Colombo, et al.
Published: (2022-02-01)