Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis

Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis

Cyclophilins have important homeostatic roles, but following tissue injury, cyclophilin A (CypA) can promote leukocyte recruitment and inflammation, while CypD can facilitate mitochondrial-dependent cell death. This study investigated the therapeutic potential of a selective cyclophilin inhibitor (G...

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Bibliographic Details
Main Authors: Khai Gene Leong, Elyce Ozols, John Kanellis, Shawn S. Badal, John T. Liles, David J. Nikolic-Paterson, Frank Y. Ma
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
cyclophilin
acute kidney injury
cell death
chronic kidney disease
inflammation
macrophage
Online Access:https://www.mdpi.com/1422-0067/22/1/271

Internet

https://www.mdpi.com/1422-0067/22/1/271

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