Transmembrane helical interactions in the CFTR channel pore.

Transmembrane helical interactions in the CFTR channel pore.

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the lung, pancreas and other organs in cystic fibrosis (CF). Development of pharmaceutica...

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Bibliographic Details
Main Authors: Jhuma Das, Andrei A Aleksandrov, Liying Cui, Lihua He, John R Riordan, Nikolay V Dokholyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5501672?pdf=render

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http://europepmc.org/articles/PMC5501672?pdf=render

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